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All of the B vitamins are needed for a healthy, functioning nervous system and several are needed to synthesize serotonin (16).Here are a few that are integrally connected to serotonin production.

Look either for serotonin boosting supplements that contain these along with the main active ingredients or add them separately with a high-quality multivitamin mineral supplement.

Before you take any serotonin supplement, it’s important to understand a little bit about them and especially how they work together.

Sometimes there are vital synergistic relationships between these various serotonin boosting substances.

Serotonin supplements like specific amino acids, vitamins, minerals and herbs increase serotonin levels helping depression and other brain-related disorders.

Serotonin is a neurotransmitter that plays a large role in mood, learning, appetite control, and sleep.

Elsewhere in Europe, it’s available as a prescription drug (8).

Unfortunately, this supplement’s usefulness for depression may be more hype than substance.

It’s particularly helpful for Parkinson’s and schizophrenia patients who also have depression (14).

SAM-e should not be mixed with drugs that affect serotonin release such as levodopa, Demerol, or Ultram, or the over-the-counter cough remedy Robitussin DM (15).

Three of the most widely used serotonin supplements are the amino acids tryptophan, 5-HTP, and SAM-e.

Note that it is not considered safe to mix any of these amino acid supplements with antidepressant medications (4).

There are several co-factors required to make the most commonly used serotonin supplements do their job.

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