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Several other brain-related disorders besides depression are related to low serotonin, including autism, ADHD, bipolar disorder, sleep disorders, and schizophrenia (3).Many people with depression or other serotonin deficiency symptoms and conditions are searching for better ways to increase serotonin levels naturally without the use of drugs.
However, tryptophan supplements can increase brain serotonin even though eating foods containing tryptophan does not (5).Elsewhere in Europe, it’s available as a prescription drug (8).Unfortunately, this supplement’s usefulness for depression may be more hype than substance.Vitamin B6 (pyridoxine): Vitamin B6 must be present to facilitate conversion of either 5-HTP or tryptophan into serotonin (17, 18).Often 5-HTP or tryptophan supplements also contain B6 for this reason.SAM-e (s-adenosyl methionine): SAM-e naturally occurs in every cell of the body and brain and fuels over 100 metabolic reactions. In Europe, SAM-e is used as a prescription medication for depression, liver disease, and osteoarthritis (11).
SAM-e supplements are synthetically derived and sold in the U. Several studies show that SAM-e works as well for depression as some anti-depression medications by increasing serotonin, dopamine, and other “feel good” brain chemicals (12, 13).If this is your situation, here are some serotonin supplements proven to help increase serotonin levels naturally.There are many kinds of nutritional supplements that increase serotonin levels — amino acids, vitamins, minerals, herbs, and more.Before you take any serotonin supplement, it’s important to understand a little bit about them and especially how they work together.Sometimes there are vital synergistic relationships between these various serotonin boosting substances.It’s particularly helpful for Parkinson’s and schizophrenia patients who also have depression (14).