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We prefer tryptophan supplements not just because studies have not conclusively found that 5-HTP helps depression, but because 5-HTP is intended for long-term use.
For decades, manufacturers shied away from selling this supplement, but it’s now readily available and widely known to be safe.
Three of the most widely used serotonin supplements are the amino acids tryptophan, 5-HTP, and SAM-e.
Note that it is not considered safe to mix any of these amino acid supplements with antidepressant medications (4).
5-HTP (5-hydroxytryptophan): 5-HTP could be considered as either an amino acid or herbal supplement.
It comes from Griffonia simplicifolia, an African woody shrub. But we’ve put it in the amino acid category since it’s so closely associated with tryptophan. S., Canada, and the United Kingdom, 5-HTP is sold as an over-the-counter supplement for ADHD, anxiety, depression, fibromyalgia, migraines, sleep disorders, and weight loss (7).
SAM-e (s-adenosyl methionine): SAM-e naturally occurs in every cell of the body and brain and fuels over 100 metabolic reactions. In Europe, SAM-e is used as a prescription medication for depression, liver disease, and osteoarthritis (11).
SAM-e supplements are synthetically derived and sold in the U. Several studies show that SAM-e works as well for depression as some anti-depression medications by increasing serotonin, dopamine, and other “feel good” brain chemicals (12, 13).
Serotonin supplements like specific amino acids, vitamins, minerals and herbs increase serotonin levels helping depression and other brain-related disorders.
Serotonin is a neurotransmitter that plays a large role in mood, learning, appetite control, and sleep.
Before you take any serotonin supplement, it’s important to understand a little bit about them and especially how they work together.
Sometimes there are vital synergistic relationships between these various serotonin boosting substances.
Several other brain-related disorders besides depression are related to low serotonin, including autism, ADHD, bipolar disorder, sleep disorders, and schizophrenia (3).